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Highlight examples of pediatric oncology nursing's accomplishments during the past 2 decades with attention to specialized practice, patient/family education, research/evidence-based practice, and advocacy and how these efforts can be leveraged to reduce disparities in the cure and care of children and adolescents with cancer. Review of currently published literature, guidelines, and websites documenting pediatric oncology nursing's contributions. Over the past 20 years, the collective work of pediatric oncology nurses ac