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Diabetes is a pandemic disease that causes relevant ocular pathologies. Diabetic retinopathy, macular edema, cataracts, glaucoma or keratopathy strongly impact the quality of life of the patients. In addition to glycemia control, intense research is devoted to find more efficient ocular drugs and improved delivery systems that can overcome eye barriers. The aim of this review is to revisit first the role of diabetes in the development of chronic eye diseases. Then, commercially available drugs and new candidates in clinical trials are t