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A recent study uncovered that Ae. aegypti mosquitoes carrying the combined Vgsc mutations L982W and F1534C manifest an extraordinarily high degree of resistance against pyrethroids. In both vertebrate and invertebrate Vgsc proteins, L982 is found within a section of high conservation. This investigation aimed to probe the viability of Ae. aegypti mosquitoes bearing the simultaneous presence of L982W and F1534C mutations in the Vgsc pro