https://www.selleckchem.com/pr....oducts/filipin-iii.h
MicroRNAs act locally and systemically to impact osteoarthritis (OA) pathophysiology, but comprehensive profiling of the circulating miRNome in early vs late stages of OA has yet to be conducted. Sequencing has emerged as the preferred method for microRNA profiling since it offers high sensitivity and specificity. Our objective was to sequence the miRNome in plasma from 91 patients with early [Kellgren-Lawrence (KL) grade 0 or 1 (n=41)] or late [KL grade 3 or 4 (n=5] symptomatic radiographic knee OA to identify unique microRNA sig
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