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The nanocomposite, by concurrently activating fluorescence and photothermal channels, diminishes intratumoral glutathione levels. Fluorescence-based tumor profiling allows for the creation of customized treatment plans based on individual characteristics. Hyperthermia induction and chemotherapy dosage are precisely controlled to guarantee treatment success, while avoiding excessive intervention. For subcutaneous orthotopic cancers with multiple tumors, an accessional therapeu