https://www.selleckchem.com/pr....oducts/adavivint.htm
Molecular docking suggested that the most active compounds 1 and 2 can be positioned within the active sites of COX-2 at Arg121 Tyr356 similar to ibuprofen (Arg-120, Glu-524, and Tyr-355). The compound 3-COX-2 complex generated by docking revealed intricate interactions with a COX-2 channel. These findings suggest that compounds 1-3 exhibited good antioxidant, antiulcer, anti-inflammatory activity and safe on liver enzymes in rats. These findings suggest that compounds 1-3 exhibited good antioxidant, antiulcer, anti-inflammatory
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