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Results highlight the importance of investigating NSSI motives associated with different symptom profiles using a multi-method approach. Results highlight the importance of investigating NSSI motives associated with different symptom profiles using a multi-method approach.Treatment of glioblastoma xenografts with chloroquine results in macroautophagy/autophagy inhibition, resulting in a reduction of tumor hypoxia and sensitization to radiation. Preclinical data show that EGFRvIII-expressing glioblastoma may benefit most from chloroquine