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This study sought to promptly examine optical coherence tomography (OCT) biomarkers for DME resistant to intravitreal anti-vascular endothelial growth factor (VEGF) treatment. A review of 72 eyes from 44 treatment-naive patients who received intravitreal anti-VEGF for DME was performed retrospectively. Evaluations of OCT scans, taken before anti-VEGF treatment, included assessment of serous retinal detachment (SRD), the extent of outer nuclear layer cystoid changes, di