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The "nurse-led" oral and maxillofacial (OMFS) head and neck (HN) clinic has been introduced and developed over the last decade, and we are now close to a point that this endeavour can potentially be implemented nationwide. This paper is a systematic review of the proposed OMFS HN nurse-led clinic model. Literature on the topic is limited only eight eligible papers were identified and reviewed. These were appraised focusing on four domains requirement/necessity, true cost, patient safety and outcomes, and education and training