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Factors including poverty prevalence (B = 232, p 0.001), GDP per capita (B = -0.23, p 0.005), and a greater proportion of reproductive-aged individuals affected by non-communicable diseases (NCDs) (B = 146, p 0.00001) were found to be associated with this risk. The second dose vaccination coverage rate was inversely correlated with the number of orphans per death (p0.005), a statistically significant finding. The elevated risk of children being orphaned by COVID-19-related deaths, in relation to the fertility rate, is due to the dispropo