https://tph104minhibitor.com/p....otts-puffy-tumour-du
The activation of LFY targets necessitates the joint action of LFY and the E3 ubiquitin ligase UFO, though the underlying mechanism remains undefined. Within the cytoplasm, we demonstrate that LFY accumulates in biomolecular condensates, while in vitro, recombinant LFY forms condensates with comparable properties. The UFO's interaction with LFY, within these condensates, flags it for destruction. Changes in total LFY levels, brought about by proteasome inhibition, UFO overexpression, or mutations to lysine r
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