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ith female **** and smoking having a negative impact on persistency. None of the anti-TNFα agents was found to be more persistent than others as first line therapy, while secukinumab was found to be superior to other biologics when indicated as second line of therapy. In this large observational cohort studied in the era of biologic therapy, a relatively low drug persistence was observed, with female **** and smoking having a negative impact on persistency. None of the anti-TNFα agents was found to be more persistent than others as first