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7, 95% confidence interval 3.4-4.1). Age-stratified risk was largely similar across diagnoses. A simple prediction model, the "DANBIO infection risk score" based on age and a count of six clinical risk factors had moderate discriminative power (internal validation AUC 0.69), which was comparable to that of the existing RABBIT risk score (external validation AUC 0.68). Patients with inflammatory joint diseases initiating bDMARD treatment had four times increased risk of serious infection compared with the general population. A simple pred