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This factor's contribution to labor initiation is also possible. Pregnancy complications, including preeclampsia (PE) and intrauterine growth restriction, related to the placenta, seem to be influenced by the apelinergic system. The exogenous administration of apelin or ELA in murine models has demonstrated an improvement in PE symptoms and birth weight. Alterations in ELA, apelin, and APJ expression are observed in human placental ti
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