https://www.selleckchem.com/products/sp-13786.html
In animal study, 4 weeks treadmill exercise upregulated claudin-1 (p less then 0.05) and occludin (p less then 0.01) protein expression level in 21 months old mice. Also, zonula occluden-1 (ZO-1) protein expression level was not significant difference among all mice group. In addition, old mice group had higher level of serum LPS compared to young mice group, but the level was downregulated in both 2 months and 21 months mice group after four weeks of treadmill exercise. Zonulin, which is known as degrading tight junction protein, is n