https://www.selleckchem.com/pr....oducts/kartogenin.ht
The ribosomal gene DNA (rDNA) often forms secondary constrictions in the chromosome; however, the molecular mechanism involved remains poorly understood. Here, we report that occurrence of rDNA constriction was increased in the chromosomes in human cancer cell lines compared with normal cells and that decondensed rDNA was significantly enhanced after partial inhibition of rDNA transcription. rDNA transcription was found during the S phase when ****tion occurred, and thus, DNA ****tion inhibitors caused constriction formation th
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