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In addition, we summarize in vivo experiments with emphasis on the effect of the activation of certain key signalings on AHN in AD rodent models. We propose that these signaling targets and corresponding interventions should be considered when developing novel therapies for AD. To estimate rates and settings of low-value imaging among pediatric Medicaid beneficiaries, and estimate associated expenditures. Retrospective longitudinal cohort study from 2014-2016 of children 18 years enrolled in Pennsylvania Medicaid. Outcomes were rates