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The effect of Ces1c/d/e deficiency on the development of metabolic syndrome was evident, but the continuous (18-week) high-fat diet exposure rendered many, though not all, observed phenotypic distinctions inconsequential. The Combined Allergic Rhinitis and Asthma Syndrome (CARAS) results in the development of chronic respiratory inflammation in individuals with allergies. Persistent exposure to particulate matter 25 (PM2.5; particles less than 25 micrometers i