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The plasma clearance, measured at 915,883 mL/min, was consistent with the twofold range of values documented for healthy individuals. Colistin's intracellular accumulation in RH/HH cells was significantly elevated by co-incubation with the MRP/Mrp inhibitor benzbromarone. In these findings, the major contribution of hepatic metabolism to the non-renal clearance of colistin is apparent, while the hepatic handling of colistin is influenced by MRP/Mrp-mediated efflux. The data we have
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