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To investigate the genetic characteristics of idiopathic central precocious puberty (ICPP) and validate its polygenic risk for early puberty. A bootstrap subsampling and genome-wide association study were performed on Taiwanese Han Chinese girls comprising 321 ICPP patients and 148 controls. Using previous GWAS data on pubertal timing, a ****tion study was performed. A validation group was also investigated for the weighted polygenic risk score (wPRS) of the risk of early puberty. A total of 105 SNPs for the risk of ICPP were identif