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this subtle variability into account.Frequent independent origins of environmental **** determination (ESD) are assumed within amniotes. However, the phylogenetic distribution of ****-determining modes suggests that ESD is likely very ancient and may be homologous across ESD groups. Sex chromosomes are demonstrated to be old and stable in endothermic (mammals and birds) and many ectothermic (non-avian reptiles) lineages, but they are mostly non-homologous between individual amniote lineages. The phylogenetic pattern may be explained by an