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A number of signaling pathways such as sirtuin and NF-kB may contribute to the mitochondrial-mediated apoptosis by resveratrol. Besides, resveratrol shifts cellular metabolism from glycolysis into mitochondrial respiration to induce cellular death in cancer cells. In the present review, we discuss the possible interactions between resveratrol and mitochondria and its potential application in cancer therapy. Copyright 2020 The Author(s).Mitochondrial failure and hypoxia are key contributors to multiple sclerosis pathophysiology. Important