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Moreover, postoperative analgesic protocols vary consistently among different centers. To date, only a few studies have evaluated the effects of the most popular VATS techniques. There is no evidence about the difference between multiport VATS and u-VATS in terms of postoperative pain. We hope that the results of our trial will provide valuable information on the outcomes of these different surgical approaches. ClinicalTrials.gov NCT03240250 . Registered on 07 August 2017; retrospectively registered. ClinicalTrials.gov NCT03240250 . Re