https://www.selleckchem.com/pr....oducts/hmpl-504-azd6
The phosphorothioate backbone modification (PS) is one of the most widely used chemical modifications for enhancing the drug-like properties of nucleic acid-based drugs, including antisense oligonucleotides (ASOs). PS-modified nucleic acid therapeutics show improved metabolic stability from nuclease-mediated degradation and exhibit enhanced interactions with plasma, cell-surface and intracellular proteins which facilitates their tissue distribution and cellular uptake in animals. However, little is known about the str
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