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Both, PCO and CON exhibited greater insulin changes on Days 1 and 7 compared to Day 0 (P less then .05). AUCglucagon were higher on Days 1 and 7 than on Day 0 (P less then .05). Changes in active GLP-1 were higher on Day 1 than Day 0 (P= .03). Overall, we showed that WPI preloading augmented insulin release and consequently lowered circulating glucose in women with and without PCOS. This insulinogenic effect can be attributed to enhanced active GLP-1 levels. We concluded that the incretin-mimetic effect of WPI may aid women with PCOS i