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Two researchers independently selected the study, extracted and managed the data. RevMan5.3 software was used to analyze the included literature. This study observed the changes of serum albumin (AL, prealbumin (PA, hemoglobin (Hb), C-reactive protein (CRP), immunoglobulin (IgG, IgA, and IgM), APACHE II score before and after treatment to evaluate the efficacy of alanyl glutamine in nutritional support therapy for patients with sepsis. This study will provide reliable evidence for the application of alanyl glutamine in nutritional sup