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Reference-free classifiers are thus a promising strategy for the identification of novel prognostic RNA biomarkers. Reference-free classifiers are thus a promising strategy for the identification of novel prognostic RNA biomarkers. Patient age is one of the most salient clinical indicators of risk from COVID-19. Age-specific distributions of known SARS-CoV-2 infections and COVID-19-related deaths are available for many regions. Less attention has been given to the age distributions of serious medical interventions administered to COVID-19