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8-635.2), p=0.03]. A strong positive association was observed between S100A1 and ZAG serum levels in patients (r=0.70, p0.0001). Serum levels of these two proteins negatively and significantly associated with BMI (r=-0.25, p=0.044 and r=-0.28, p=0.024, respectively) and arm circumference (r=-0.26, p=0.037 and r=-0.25, p=0.047, respectively). The results indicate that S100A1 and ZAG are likely to contribute to the pathogenesis of HF disease and weight loss, as well as the strong association between S100A1 and ZAG possibly indicating