https://www.selleckchem.com/products/sant-1.html
Here, we tested the hypothesis that mGluR1/5 recruit Orai1 as part of its downstream signaling pathway in dorsal horn neurons. We demonstrate that neurotransmitter glutamate induces STIM1 puncta formation, which is not mediated by NMDA or AMPA receptors. Glutamate-induced Ca2+ entry in the presence of NMDA/AMPA receptor antagonists is eliminated in Orai1-deficient neurons. DHPG (an agonist of mGluR1/5)-induced Ca2+ entry is abolished by Orai1 deficiency, but not affected by knocking down of TRPC1 or TRPC3. DHPG-induced activation of ERK1
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