https://www.selleckchem.com/pr....oducts/lanifibranor-
We combined mRNA display technology with lipid-nanodisc based selections and identified high-affinity ligands targeting the integral membrane sensor domain of the histidine kinase AgrC as potent inhibitors of Staphylococcus aureus quorum sensing-modulated virulence. Our study highlights the potential of this integrated approach for identifying functional modulators of integral membrane proteins.Synthetic DNA analogues are of great interest for their application in information storage, therapeutics, and nanostructured materi
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