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Further investigations showed that silencing Celsr2 inhibited the phosphorylation of GSK3β. Moreover, specific activators of the Wnt/β-catenin pathway, LiCl or mutant β-catenin (S33Y), partially reversed the inhibitory effect of Celsr2 siRNA. Taken together, our data indicated that silencing Celsr2 inhibited Schwann cells migration and proliferation through the suppressing Wnt/β-catenin pathway, providing a potential target for peripheral nerve regeneration. We aim to examine the location of the vascular equator according to the umbilic