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A practical synthetic pathway was developed for 4-aryl-13,4-benzotriazepinones, leveraging the readily available isatoic anhydrides and hydrazonyl chlorides as starting materials. Employing this straightforward methodology, a diverse range of 13,4-benzotriazepinones bearing functional groups were efficiently prepared, highlighting broad substrate scope and excellent functional group tolerance. The presence of pathogenic microbes in the gut, a consequence of poor h
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