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We then present a fully Bayesian treatment of this formalism, which enables the incorporation of powerful Bayesian tools such as the inclusion of regularizing priors, uncertainty quantification, and model selection techniques. We demonstrate this new formalism in the analysis of umbrella sampling simulations for the χ torsion of a valine side chain in the L99A mutant of T4 lysozyme with benzene bound in the cavity.Terminal deoxynucleotidyl transferase (TdT) catalyzes template free incorporation of arbitrary nucleotides onto single-stra
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