https://www.selleckchem.com/pr....oducts/ccs-1477-cbp-
A short, scalable, and collective total synthesis of four fawcettimine-type Lycopodium alkaloids in eight or nine steps is disclosed. A dense multi-small-ring spiro-α-aminocyclopentanone successfully served as the key intermediate, which was directly accessed by a LiDBB-mediated intramolecular reductive coupling of the aliphatic imine and an ester-carbonyl. Compared to those that employ classical Heath**** intermediate(s) containing a nine-membered ring, the new strategy shows the significant improvement of the synthetic step
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