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VTn-mediated effects resulted in a disproportionate number of M1 macrophages, actively producing TNF at the wound site, but these macrophages were nonetheless ineffective in removing the persistent neutrophil population. Caspase-1 and caspase-11 were the crucial components in the caspase-1 and caspase-11-dependent process through which IL-1 and IL-1 mediated chronic neutrophilic inflammation and senesc