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Due to this, we detected a surge in Cdk2, a downstream target of p21, implying an accelerated G1/S phase transition in the Hdac1-deficient zebrafish's hearts. Remarkably reduced was the expression of Cdk1, a further target of both p21 and Cdc25. Analysis of Hdac1-deficient zebrafish embryos revealed a considerable reduction in Cdc25 protein expression, thereby accounting for the decreased Cdk1 levels and suggesting