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More alterations were observed in liver after exposure to Acer 35 EC. In both ****es, IBR values were higher after 56 days than after 28 days of exposure. In conclusion, based on a large set of biomarkers and IBR values, the chronic exposure to low doses of insecticide Acer 35 EC seems to impair different physiological functions in Nile tilapia juveniles on a time-dependent manner, with a stronger impact on females than on males. To report on the multidisciplinary approach, focusing specifically on the role of the interventional radiologis