https://www.selleckchem.com/pr....oducts/iacs-010759-i
6% vs 24.2% vs 25.0%, P = .028), compared to those with I/M (n = 66) and I/I (n = 8 PNPLA3 genotype. The association of I148M homozygosity with lower e-GFR levels (P less then .0001) and higher risk of CKD (adjusted-odds ratio 6.65; 95% CI 1.65-26.8, P = .008) was independent of liver disease severity (as detected by liver stiffness ≥7kPa) and other risk factors. PNPLA3 mRNA expression was greatest in liver and renal cortex, and podocytes showed high PNPLA3 mRNA and protein levels, comparable to that of hepatocytes and
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