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Identification experiments showed that HA led to heightened expression of AQP4, Bcl-xl, the p-Akt/AKT ratio and Bcl-xl/Bax ratio, and decreased levels of Cleaved Caspase-3. By ameliorating cerebral edema and cellular apoptosis, the HA model effectively lessens EHS-related brain damage, offering experimental proof of EHS prophylaxis. Comparing visual acuity results achieved with long-term steroid versus