https://dihydroethidiumchemica....l.com/syndecan-1-mod
Further investigation using an in-cell NanoBRET assay demonstrates that these heterobifunctional molecules are cell-permeable, forming ternary complexes, and effectively degrade nanoluciferase-bromodomain fusions. In a first demonstration of CECR2 degradation, our pyrimidine-based analogues selectively degrade endogenous CECR2 while demonstrating less effect on the levels of BPTF. Further invest