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Administration of moderate and high doses of LS extracts to both male and female rats resulted in a tendency for increased transcription of six CYP450 enzymes. The CYP2E1 gene showed a unique level of expression in male rats receiving SE at a dose of 2000 milligrams per kilogram of body weight. While a low dose of 300 milligrams per kilogram of body weight was observed in the female group treated with LW. Accordingly, our results propose that v