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The emergence of recent SARS-CoV-2 has become a global health issue. This single-stranded positive-sense RNA virus is continuously spreading with increasing morbidities and mortalities. The proteome of this virus contains four structural and sixteen nonstructural proteins that ensure the ****tion of the virus in the host cell. However, the role of phosphoprotein (N) in RNA recognition, ****ting, transcribing the viral genome, and modulating the host immune response is indispensable. Recently, the NMR structure of the N-terminal dom