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HEIH warrants further investigation as a potential prognostic marker for patients confronting cancer. This research sought to determine the pathway through which Duhuo Jisheng Decoction (DHJSD) impacts intervertebral disc degeneration (IVDD). Employing the TCMSP database, the active compounds of DHJSD and their related targets were ascertained. Disease-related targets were identified by searching for "intervertebral disc degeneration" in DisGeNET, GeneCards, the Comparative Toxicogen