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Superior control of M. abscessus growth and increased survival in flies lacking Tep4 opsonin, as we demonstrate, are correlated with the overproduction of certain antimicrobial peptides, including defensin. Furthermore, extracellular M. abscessus was entirely eradicated by defensin treatment, proving its effectiveness in both laboratory and live-animal models, thus controlling infection. The data obtained collectively show that M. abscessus, when opsonized by
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