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ss patient compliance with vitamin D supplementation and impact on patients' vitamin D levels. Biomarkers in clinical trials have led to massive incorporation of research biopsies, with potentially risks and no direct benefit for patients. In 2018, the American Society of Clinical Oncology (ASCO) released an ethical framework to provide guidance on incorporating research biopsies in cancer clinical trials. We collected biopsy requirements of cancer clinical trials conducted at Institut Jules Bordet (IJ between 2015 an