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To assess liver injury indicators in liver and serum, four groups of mice (Sham, TBI, APAP, and TBI+APAP) were examined using Western blot, RT-PCR, and immunohistochemical staining. The liver injury response to early-stage brain trauma showed signs of recovery within three days; however, this recovery phase was insufficient to prevent a considerable worsening of drug-induced liver injury (DILI). This worsening was indicated by
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