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Psychiatric illnesses, including depression and anxiety, are highly comorbid with epilepsy (for review see Josephson and Jetté (Int Rev Psychiatry 29409-424, 2017), Salpekar and Mula (Epilepsy Behav 98293-297, 2019)). Psychiatric comorbidities negatively impact the quality of life of patients (Johnson et al., Epilepsia 45544-550, 2004; Cramer et al., Epilepsy Behav 4515-521, 2003) and present a significant challenge to treating patients with epilepsy (Hitiris et al., Epilepsy Res 75192-196, 2007; Petrovski et al., Neurology 751015-1021, 2
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