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Due to the presence of neurotransmitters and neuropeptides within the tumor microenvironment (TME), immune cells experience phenotypic changes, particularly an increase in exhaustion and inhibition of effector cells, which enables immune escape and fuels cancer progression. This review addresses two modes of immune regulation employed by nerves that associate with tumors: regulation via neuronal stimuli (such as neuronal transmission) and checkpoint-mediated neur
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