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The CCS mapping strategy's bias reduction, at least 30% lower than those observed with pooled RR and data dimension strategies, is quantified by RMSE values of 0.14, 0.19, and 0.21, respectively, in this scenario. To minimize residual bias in pharmacoepidemiologic studies using HDPS across varying ICD coding periods, a helpful tactic is to map ICD codes to a stable system such as CCS. To reduce residual bias within pharmacoepidemiological stu
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