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(1) Background The etiology of orofacial cleft (OC) is not completely known but several genetic and environmental risk factors have been identified. Moreover, a knowledge gap still persists regarding neonatal characteristics. This study evaluated the effect of parental age and mothers' body mass index on the risk of having an OC child, in a matched year and **** group (cleft/healthy control). Additionally, birth data were analyzed between groups. (2) Methods 266 individuals born between 1995 to 2015 were evaluated 133 OC individuals (85